If neurological compromise is noted, urgent treatment is necessary.Ĭonsider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated. Monitor patients frequently for signs and symptoms of neurological impairment. optimal timing between the administration of ELIQUIS and neuraxial procedures is not known.a history of spinal deformity or spinal surgery.a history of traumatic or repeated epidural or spinal punctures.
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If anticoagulation with ELIQUIS is discontinued for a reason other than pathological bleeding or completion of a course of therapy, consider coverage with another anticoagulant. (A) Premature discontinuation of any oral anticoagulant, including ELIQUIS ® (apixaban), increases the risk of thrombotic events. WARNING: (A) PREMATURE DISCONTINUATION OF ELIQUIS INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA SELECTED IMPORTANT SAFETY INFORMATION IMPORTANT SAFETY INFORMATION MORE IMPORTANT SAFETY INFORMATION